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Index > Protein center > Crbn(Gene name) > Mouse
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  • Crbn (Gene name),
  • Protein cereblon (Protein name ),  CRBN_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Crbn;
    Protein name:
    Protein cereblon(Protein PiL);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of a DCX (DDB1-CUL4-X-box) protein ligase complex, at least composed of CRBN, CUL4A, DDB1 and RBX1. Interacts with KCNT1.
    Function:
    Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.
    Subcellular Location:
    Cytoplasm Nucleus Membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    445
    Sequence:
    50:
    MAGEGDQQDA | AHNMGNHLPL | LPADSEDEDD | EIEMEVEDQD | SKEARKPNII | 
    100:
    NFDTSLPTSH | TYLGADMEEF | HGRTLHDDDS | CQVIPVLPEV | LMILIPGQTL | 
    150:
    PLQLSHPQEV | SMVRNLIQKD | RTFAVLAYSN | VQEREAQFGT | TAEIYAYREE | 
    200:
    QEFGIEVVKV | KAIGRQRFKV | LELRTQSDGI | QQAKVQILPE | CVLPSTMSAV | 
    250:
    QLESLNKCQV | FPSKPISWED | QYSCKWWQKY | QKRKFHCANL | TSWPRWLYSL | 
    300:
    YDAETLMDRI | KKQLREWDEN | LKDDSLPENP | IDFSYRVAAC | LPIDDVLRIQ | 
    350:
    LLKIGSAIQR | LRCELDIMNK | CTSLCCKQCQ | ETEITTKNEI | FSLSLCGPMA | 
    400:
    AYVNPHGYVH | ETLTVYKASN | LNLIGRPSTV | HSWFPGYAWT | IAQCKICASH | 
    445:
    IGWKFTATKK | DMSPQKFWGL | TRSALLPTIP | ETEDEISPDK | VILCL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Protein PiL
    Cat.:
    E12793h
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    Packing:
    96T
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    ELISA Kit for Mouse Protein PiL
    MSDS:
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    ELISA Kit for Mouse Protein PiL
    MSDS:
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    ELISA Kit for Mouse Protein PiL
    Cat.:
    E12793m
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    Packing:
    96T
    ELISA Kit for Mouse Protein PiL
    Cat.:
    E12793r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Protein PiL
    Cat.:
    U12793r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Protein PiL
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Protein PiL
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Protein PiL
    Cat.:
    U12793h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Protein PiL
    Cat.:
    U12793m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Protein PiL
    Cat.:
    P12793Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Protein PiL
    Polyclonal Antibody for Mouse Protein PiL
    Polyclonal Antibody for Mouse Protein PiL
    Polyclonal Antibody for Mouse Protein PiL
    Monoclonal Antibody for Mouse Protein PiL
    Monoclonal Antibody for Mouse Protein PiL
    Monoclonal Antibody for Mouse Protein PiL
    Monoclonal Antibody for Mouse Protein PiL
    Monoclonal Antibody for Mouse Protein PiL
    Protein for Mouse Protein PiL
    Protein for Mouse Protein PiL
    Protein for Mouse Protein PiL
    Protein for Mouse Protein PiL
    Protein for Mouse Protein PiL

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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      strain: C57BL/6J.
      tissue: Head.
      tissue: Pancreas.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-445 (ISOFORM 1)
      tissue: Eye.
    3. 3.
      "A novel gene mutated in R197 insertional mutant mice."
      Rose J.B. , van Driel I.R. , Tan S.
      Submitted (2000-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-445
    4. 4.
      "Temporal and spatial mouse brain expression of cereblon, an ionic channel regulator involved in human intelligence."
      Higgins J.J. , Tal A.L. , Sun X. , Hauck S.C. , Hao J. , Kosofosky B.E. , Rajadhyaksha A.M.
      J. Neurogenet.24:18-26(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    5. 5.
      "Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability."
      Rajadhyaksha A.M. , Ra S. , Kishinevsky S. , Lee A.S. , Romanienko P. , DuBoff M. , Yang C. , Zupan B. , Byrne M. , Daruwalla Z.R. , Mark W. , Kosofsky B.E. , Toth M. , Higgins J.J.
      Behav. Brain Res.226:428-434(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    6. 6.
      "Structure of the human cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs."
      Chamberlain P.P. , Lopez-Girona A. , Miller K. , Carmel G. , Pagarigan B. , Chie-Leon B. , Rychak E. , Corral L.G. , Ren Y.J. , Wang M. , Riley M. , Delker S.L. , Ito T. , Ando H. , Mori T. , Hirano Y. , Handa H. , Hakoshima T. , more...
      Nat. Struct. Mol. Biol.21:803-809(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 322-430 IN COMPLEX WITH S-THALIDOMIDE AND ZINC;DOMAIN
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