Protein name:
Protein cereblon (Protein PiL) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of a DCX (DDB1-CUL4-X-box) protein ligase complex, at least composed of CRBN, CUL4A, DDB1 and RBX1. Interacts with KCNT1.
Function:
Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.
Subcellular Location:
Cytoplasm
Nucleus
Membrane
Peripheral membrane protein
Protein Attributes:
50:
MAGEGDQQDA | AHNMGNHLPL | LPADSEDEDD | EIEMEVEDQD | SKEARKPNII |
100:
NFDTSLPTSH | TYLGADMEEF | HGRTLHDDDS | CQVIPVLPEV | LMILIPGQTL |
150:
PLQLSHPQEV | SMVRNLIQKD | RTFAVLAYSN | VQEREAQFGT | TAEIYAYREE |
200:
QEFGIEVVKV | KAIGRQRFKV | LELRTQSDGI | QQAKVQILPE | CVLPSTMSAV |
250:
QLESLNKCQV | FPSKPISWED | QYSCKWWQKY | QKRKFHCANL | TSWPRWLYSL |
300:
YDAETLMDRI | KKQLREWDEN | LKDDSLPENP | IDFSYRVAAC | LPIDDVLRIQ |
350:
LLKIGSAIQR | LRCELDIMNK | CTSLCCKQCQ | ETEITTKNEI | FSLSLCGPMA |
400:
AYVNPHGYVH | ETLTVYKASN | LNLIGRPSTV | HSWFPGYAWT | IAQCKICASH |
445:
IGWKFTATKK | DMSPQKFWGL | TRSALLPTIP | ETEDEISPDK | VILCL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Chicken
Mouse
Rat
ELISA Kit for Mouse Protein PiL
ELISA Kit for Mouse Protein PiL
ELISA Kit for Mouse Protein PiL
ELISA Kit for Mouse Protein PiL
ELISA Kit for Mouse Protein PiL
CLIA Kit for Mouse Protein PiL
CLIA Kit for Mouse Protein PiL
CLIA Kit for Mouse Protein PiL
CLIA Kit for Mouse Protein PiL
CLIA Kit for Mouse Protein PiL
Polyclonal Antibody for Mouse Protein PiL
Polyclonal Antibody for Mouse Protein PiL
Polyclonal Antibody for Mouse Protein PiL
Polyclonal Antibody for Mouse Protein PiL
Polyclonal Antibody for Mouse Protein PiL
Monoclonal Antibody for Mouse Protein PiL
Monoclonal Antibody for Mouse Protein PiL
Monoclonal Antibody for Mouse Protein PiL
Monoclonal Antibody for Mouse Protein PiL
Monoclonal Antibody for Mouse Protein PiL
Protein for Mouse Protein PiL
Protein for Mouse Protein PiL
Protein for Mouse Protein PiL
Protein for Mouse Protein PiL
Protein for Mouse Protein PiL
R&D Technical Data
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Precision
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Recovery
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Linearity
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
strain :
C57BL/6J .
tissue :
Head .
tissue :
Pancreas .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-445 (ISOFORM 1)
tissue :
Eye .
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Submitted (2000-01) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 8-445
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 322-430 IN COMPLEX WITH S-THALIDOMIDE AND ZINC;DOMAIN